Bayer Leverkusen - Atletico Madrid
Bayer Leverkusen are struggling in the Bundesliga this season and face a tough task as they host last season's losing finalists Atletico Madrid in the Champions League.
Manchester City - Monaco
Manchester City have the best chance of qualifying of the English teams left in the Champions League. They will be looking for a good lead to take to Monaco for the second leg.
Sevilla FC - Leicester City
Sevilla have won the Europa League for the past two seasons but have their eyes set on a larger prize this time around. They can take huge strides toward reaching the Champions League quarter finals with a home win over out-of-form Leicester City.
Huddersfield Town - Reading
Huddersfield are in top form at present and host Reading in a Championship promotion battle with both sides still hoping to finish in the top two.
Sheffield Wednesday - Brentford
Sheffield Wednesday look booked for another play-off spot in the Championship. They can keep their good run going with a home win over inconsistent Brentford.
Bristol City - Fulham
Bristol City are in deep relegation trouble and need the points as they host Fulham who still have an outside chance of making the play-offs.
FC Krasnodar - Fenerbahce
Fenerbahce who are fourth on the Super Lig table will be playing host to their Russian counterparts Krasnodar in the return match of the second round of the UEFA Europa League on Wednesday 22 February.
PAOK - Schalke 04
Schalke 04 will host PAOK in the return leg of the second round of the UEFA Europa League on Wednesday 22 February.
St Etienne - Manchester United
It looks like mission impossible for St Etienne as they begin their home leg against Manchester United trailing 3-0. It could be another difficult night for the French side.
Valencia - Real Madrid
Real Madrid are only a point clear of Barcelona at the top of La Liga but have two games in hand. The first of those is away to Valencia who are only three places above the relegation zone.
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